Bone Marrow-Derived Progenitor Cells in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

• DOI: 10.1161/strokeaha.109.563726
• Publication Date: 2009-12-25T02:51:27Z
• Authors: Francesca Pescini; Francesca Cesari; Betti Giusti; Cristina Sarti; Enza Zicari; Silvia Bianchi; Maria T. Dotti; Antonio Federico; Maurizio Balestrino; Adriano Enrico; Carlo Gandolfo; Anna M. Gori; Rosanna Abbate; Leonardo Pantoni; Domenico Inzitari
• Keywords: CADASIL; Vasculogenesis; Stroke

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited disease due to cerebral microangiopathy presenting variable pictures, including stroke, progressive cognitive impairment, disability. Mechanisms leading from vessel structural changes parenchymal damage eventually clinical expression are not fully understood. Among pathogenic processes, endothelial dysfunction has been hypothesized. Endothelial progenitor cells circulating (CPCs) derived bone marrow participate in endothelium structure function maintenance contribute ischemic area revascularization. No data available about these CADASIL. Our objective this study was evaluate CPCs role CADASIL.Twenty-nine patients CADASIL 29 sex- age-matched control subjects were enrolled. Cells measured peripheral blood using flow cytometry. defined as positive for CD34/KDR, CD133/KDR, CD34/CD133/KDR; CD34, CD133, CD34/CD133.Endothelial significantly lower than (CD34/KDR: 0.05 versus 0.1 cells/microL, P=0.005; CD133/KDR: 0.07 P=0.006; CD34/CD133/KDR: P=0.001). The difference remained significant after adjusting age, sex, statin use. CADASIL, but stroke or dementia had reduced CPC levels without (CD34: 1.68 2.95 P=0.007; CD133: 1.40 2.82 P=0.004; CD34/CD133: 1.44 2.75 P=0.004). correlated motor performance measures.We have documented association between extending previous the presence of its potential modulating phenotype.