The X-Chromosome Has a Different Pattern of Gene Expression in Women Compared With Men With Ischemic Stroke

• DOI: 10.1161/strokeaha.111.629337
• Publication Date: 2011-11-04T05:03:03Z
• Authors: Boryana Stamova; Yingfang Tian; Glen Jickling; Cheryl Bushnell; Xinhua Zhan; Dazhi Liu; Bradley P. Ander; Piero Verro; Vihar Patel; William C. Pevec; Nasim Hedayati; David L. Dawson; Edward C. Jauch; Arthur Pancioli; Joseph P. Broderick; Frank R. Sharp
• Keywords: Stroke

Differences in ischemic stroke between men and women have been mainly attributed to hormonal effects. However, sex differences immune response ischemia may exist. We hypothesized that differential expression of X-chromosome genes blood cells contribute with stroke.RNA levels 683 were measured on Affymetrix U133 Plus2.0 microarrays. Blood samples from patients obtained at ≤ 3 hours, 5 24 hours (n=61; 183 samples) after onset compared control subjects without symptomatic vascular diseases (n=109). Sex difference gene was determined using analysis covariance (false discovery rate 0.05, fold change ≥ 1.2).At 3, 5, stroke, there 37, 140, 61 genes, respectively, changed women; 23, 18, 31 men. Female-specific associated post-translational modification, small-molecule biochemistry, cell-cell signaling. Male-specific cellular movement, development, cell-trafficking, cell death. Altered specific occurred 2 known be human including galactosidase A IDS, mutations which result Fabry disease Hunter syndrome, respectively.There are stroke. Future studies needed decipher whether these sexually dimorphic response, repair or other mechanisms some them represent risk determinants.