Risk of Recurrent Stroke in Patients With Silent Brain Infarction in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) Imaging Substudy

• DOI: 10.1161/strokeaha.111.631739
• Publication Date: 2012-01-21T02:19:29Z
• Authors: Ralph Weber; Christian Weimar; Isabel Wanke; Claudia Möller-Ha...; Elke R. Gizewski; Jon Blatchford; Karin Hermansson; Andrew M. Demchuk; Michael Forsting; Ralph L. Sacco; Jeffrey L. Saver; Steven Warach; Hans Christoph Di...; Anke Diehl
• Keywords: Stroke; Regimen

Background and Purpose— Silent brain infarctions are associated with an increased risk of stroke in healthy individuals. Risk recurrent patients both symptomatic silent infarction (SBI) has only been investigated cardioembolic the European Atrial Fibrillation Trial. We assessed whether recent noncardioembolic SBI detected on MRI at for stroke, other cardiovascular events, mortality. Methods— The prevalence was 1014 enrolled imaging substudy Prevention Regimen Effectively Avoiding Second Strokes (PRoFESS) trial. primary outcome first recurrence comparison age- sex-matched without SBI. Secondary outcomes were a combined vascular end point, 2 groups compared using conditional logistic regression. Results— 207 (20.4%) patients. Twenty-seven (13.0%) 19 (9.2%) had (OR, 1.42; 95% CI, 0.79–2.56; P =0.24) during mean follow-up 2.5 years. Similarly, there no statistically significant difference all secondary parameters between matched Conclusions— presence mild ischemic could not be shown to independent factor or higher mortality rate. Clinical Trial Registration— URL: http://clinicaltrials.gov . Unique identifier: NCT00153062.