Impact of Early Blood Pressure Variability on Stroke Outcomes After Thrombolysis

• DOI: 10.1161/strokeaha.112.681007
• Publication Date: 2013-01-18T05:09:07Z
• Authors: Kaoru Endo; Kazuomi Kario; Masatoshi Koga; Jyoji Nakagawara; Yoshiaki Shiokawa; Hiroshi Yamagami; Eisuke Furui; Kazumi Kimura; Yasuhiro Hasegawa; Yasushi Okada; Satoshi Okuda; Michito Namekawa; Tetsuya Miyagi; Masato Osaki; Kazuo Minematsu; Kazunori Toyoda
• Keywords: Stroke; Acute stroke

The present study determines associations between early blood pressure (BP) variability and stroke outcomes after intravenous thrombolysis.In 527 patients receiving alteplase (0.6 mg/kg), BP was measured 8 times within the first 25 hours. determined as ΔBP (maximum-minimum), standard deviation (SD), coefficient of variation, successive variation.The systolic course lower among with modified Rankin Scale (mRS) 0 to 1 than those without (P<0.001). Most profiles were significantly associated outcomes. Adjusted odds ratios (95% confidence interval) per 10 mm Hg (or 10% for variation) on symptomatic intracerebral hemorrhage follows: ΔBP, 1.33 (1.08-1.66); SD, 2.52 (1.26-5.12); 3.15 (1.12-8.84); 1.82 (1.04-3.10). respective values 0.88 (0.77-0.99), 0.73 (0.48-1.09), 0.77 (0.43-1.34), 0.76 (0.56-1.03) 3-month mRS 1; 1.40 (1.14-1.75), 2.85 (1.47-5.65), 4.67 (1.78-12.6), 1.99 (1.20-3.25) death. Initial before thrombolysis not any outcomes.Early positively death thrombolysis.