External Validation of Risk Scores for Major Bleeding in a Population-Based Cohort of Transient Ischemic Attack and Ischemic Stroke Patients

• DOI: 10.1161/strokeaha.117.019259
• Publication Date: 2018-02-19T10:05:13Z
• Authors: Nina A. Hilkens; Linxin Li; Peter M. Rothwell; Ale Algra; Jacoba P. Greving
• Keywords: Bleed; Stroke; Statistic

The S2TOP-BLEED score may help to identify patients at high risk of bleeding on antiplatelet drugs after a transient ischemic attack or stroke. was derived trial populations, and its performance in real-world setting is unknown. We aimed externally validate the for major population-based cohort compare with other scores bleeding.We studied 2072 stroke agents OXVASC (Oxford Vascular Study) according 3 scores: S2TOP-BLEED, REACH, Intracranial-B2LEED3S. Performance assessed C statistics calibration plots.During 8302 patient-years follow-up, 117 had bleed. showed statistic 0.69 (95% confidence interval [CI], 0.64-0.73) accurate 3-year bleeding. much more predictive fatal than nonmajor (C 0.77; 95% CI, 0.69-0.85 0.50; 0.44-0.58). REACH 0.63 0.58-0.69) Intracranial-B2LEED3S 0.60 0.51-0.70) intracranial ratio events versus bleeds decreased across groups from 6.6:1 low-risk group 1.8:1 high-risk group.The shows modest Although risks were associated events, stratification still be useful subgroup particularly bleeding, whom preventive measures are indicated.