Cav-1 (Caveolin-1) and Arterial Remodeling in Adult Moyamoya Disease

• DOI: 10.1161/strokeaha.118.021888
• Publication Date: 2018-10-15T09:14:56Z
• Authors: Jong-Won Chung; Dong Hee Kim; Mi Jeong Oh; Yeon Hee Cho; Eun Hee Kim; Gyeong Joon Moon; Chang-Seok Ki; Jihoon Cha; Keon Ha Kim; Pyoung Jeon; Je Young Yeon; Gyeong-Moon Kim; Jong-Soo Kim; Seung Chyul Hong; Oh Young Bang
• Keywords: Moyamoya Disease; Stroke; Arteriogenesis

Background and Purpose— Moyamoya disease (MMD) is a unique cerebrovascular occlusive characterized by progressive stenosis negative remodeling of the distal internal carotid artery (ICA). We hypothesized that cav-1 (caveolin-1)—a protein controls regulation endothelial vesicular trafficking signal transduction—is associated with in MMD. Methods— prospectively recruited 77 consecutive patients MMD diagnosed via conventional angiography. Seventeen intracranial atherosclerotic stroke no RNF213 mutation served as controls. The outer ICA diameters were examined using high-resolution magnetic resonance imaging. evaluated whether degree was polymorphism, levels, or various clinical vascular risk factors. also investigated derived factor at cellular level tube formation apoptosis assays. Results— serum lower than (0.47±0.29 versus 0.86±0.68 ng/mL; P =0.034). mean diameter 2.48±0.98 mm for 126 affected ICAs 3.84±0.42 asymptomatic ( <0.001). After adjusting confounders, levels (coefficient, 1.018; <0.001) independently In vitro analysis showed downregulation suppressed angiogenesis cells induced smooth muscle cells. Conclusions— Our findings suggest may play major role arterial