Effect of Cognitive Reserve on Risk of Cognitive Impairment and Recovery After Stroke

• DOI: 10.1161/strokeaha.119.026829
• Publication Date: 2019-12-11T10:00:25Z
• Authors: Minyoung Shin; Min Kyun Sohn; Jongmin Lee; Deog Young Kim; Sam-Gyu Lee; Yong-Il Shin; Gyung-Jae Oh; Yang-Soo Lee; Min Cheol Joo; Eun Young Han; Junhee Han; Jeonghoon Ahn; Won Hyuk Chang; Min A Shin; Ji Yoo Choi; Sung Hyun Kang; Youngtaek Kim; Yun-Hee Kim
• Keywords: Stroke; Cognitive reserve; Odds

Background and Purpose— The theory of cognitive reserve (CR) was introduced to account for individual differences in the clinical manifestation neuropathology. This study investigated whether CR has a modulating effect on impairment recovery after stroke. Methods— is an interim analysis Korean Stroke Cohort Functioning Rehabilitation. A total 7459 patients with first-ever stroke were included analysis. Education, occupation, composite scores derived from those 2 variables used as proxies. Scores version Mini-Mental State Examination analyzed 30 months onset analyzed. Results— Lower increased risk odds ratio 1.89 (95% CI, 1.64–2.19) secondary education 2.42 2.03–2.90) primary compared higher education. 1.48 1.23–1.98) skilled manual occupation 2.01 1.42–2.83) nonskilled managerial or professional occupation. In multilevel model analysis, score during first 3 (1.93 points per month) then plateaued (0.02 point month). slopes moderated by level education, score: score, faster recovery. older adult group, showed long-term decline that level. Conclusions— Education can buffer against caused promote rapid early addition, minimizes stroke, especially patients. Clinical Trial Registration— URL: https://www.clinicaltrials.gov . Unique identifier: NCT03402451.