Effect of Heart Rate on Stroke Recurrence and Mortality in Acute Ischemic Stroke With Atrial Fibrillation

• DOI: 10.1161/strokeaha.119.026847
• Publication Date: 2019-12-04T10:00:25Z
• Authors: Keon-Joo Lee; Beom Joon Kim; Moon-Ku Han; Joon-Tae Kim; Kang-Ho Choi; Dong-Ick Shin; Min-Ju Yeo; Jae-Kwan Cha; Dae-Hyun Kim; Hyun-Wook Nah; Dong-Eog Kim; Wi-Sun Ryu; Jong-Moo Park; Kyusik Kang; Soo Joo Lee; Jae Guk Kim; Mi-Sun Oh; Kyung-Ho Yu; Byung-Chul Lee; Keun-Sik Hong; Yong-Jin Cho; Jay Chol Choi; Tai Hwan Park; Sang-Soon Park; Jee-Hyun Kwon; Wook-Joo Kim; Jun Lee; Ji Sung Lee; Juneyoung Lee; Philip B. Gorelick; Hee-Joon Bae
• Keywords: Stroke

Background and Purpose- There is a paucity of information about the role resting heart rate in prediction outcome events patients with ischemic stroke atrial fibrillation. We aimed to investigate relationships between level variability acute period recurrence mortality after Methods- Acute who had fibrillation were hospitalized within 48 hours onset identified from multicenter prospective registry database. The was divided into early (within 24 hospitalization) late (72 7 days onset) stages, data on both stages collected. Moreover, assessed using mean values coefficients variation. Outcome prospectively monitored up 1 year index stroke. Results- Among 2046 eligible for stage analysis, 102 (5.0%) recurrence, 440 (21.5%) died during first A statistically significant nonlinear J-shaped association observed (P<0.04 quadratic overall effect) but not (P>0.1 effect). effects variation all variables. same results analysis (n=1576). Conclusions- In stroke, associated (nonlinear, association). outcomes respect variability.