Effect of Imaging Selection Paradigms on Endovascular Thrombectomy Outcomes in Patients With Acute Ischemic Stroke

• DOI: 10.1161/strokeaha.122.042203
• Publication Date: 2023-05-11T09:04:31Z
• Authors: Jian Miao; Hongfei Sang; Fengli Li; Jeffrey L. Saver; Bo Lei; Jinglun Li; Raul Gomes Nogueira; Bo Song; Shudong Liu; Thanh N. Nguyen; Zhenglong Jin; Hongliang Zeng; Changming Wen; Guangxiong Yuan; Weilin Kong; Weidong Luo; Shuai Liu; Dongjing Xie; Jiacheng Huang; Chang Liu; Jie Yang; Jinrong Hu; Jiaxing Song; Chengsong Yue; Linyu Li; Yan Tian; Xiao Zhang; Dan Feng; Yani Gao; Huiying Fu; Wenjie Zi; Qingwu Yang; Zhongming Qiu; Shaojun Wang
• Keywords: Stroke; Computed Tomography Angiography; Tirofiban

The effect of imaging selection paradigms on endovascular thrombectomy outcomes in patients with acute ischemic stroke large vessel occlusion remains uncertain. study aimed to assess the basic (noncontrast computed tomography or without tomographic angiography) versus advanced (magnetic resonance perfusion) clinical following early and extended windows using a pooled analysis patient-level data from 2 pivotal randomized trials done China.This post hoc used 1182 included multicenter, controlled China that evaluated adjunct therapies treatment for (Direct Endovascular Treatment Large Artery Anterior Circulation Stroke performed May 20, 2018, through 2, 2020, Intravenous Tirofiban Before October 10, 31, 2021). Patients intracranial internal carotid artery proximal middle cerebral (M1/M2 segments) were categorized according baseline modality (basic advanced) as well time window (early, 0-6 hours extended, 6-24 last known puncture). primary outcome was proportion functional independence (modified Rankin Scale score 0-2) at 90 days. Multivariable Poisson regression determine association between after each windows.A total this cohort analysis, 648 (471 177 imaging) 534 (222 312 window. There no differences 90-day groups either (early window: adjusted relative risk, 0.99 [95% CI, 0.84-1.16]; P=0.91; 1.00 0.84-1.20]; P=0.97).In trial involving stroke, an safety undergoing not detected. Our adds growing body literature simpler eligibility across both windows.URL: http://www.chictr.org.cn; Unique identifiers: ChiCTR-IOR-17013568 ChiCTR-INR-17014167.