Abstract Number ‐ 255: Laser Speckle Flowgraphy As A Surrogate Marker For Symptomatic Carotid Stenosis

• DOI: 10.1161/svin.03.suppl_1.255
• Publication Date: 2023-04-25T07:32:42Z
• Authors: Matthew T Jones; Sebastian Sanchez; Rishi R Patel; Jacob M Miller; Ashrita Raghuram; Randy Kardon; Edgar Samaniego
• Keywords: Digital subtraction angiography

Introduction The severity of internal carotid artery (ICA) atherosclerosis is assessed through measurements degree stenosis. This approach does not factor in mechanisms compensating for reduced distal perfusion, such as collateral circulation. An alternative evaluating stenosis based on downstream changes ocular perfusion. Laser speckle flowgraphy (LSFG) a non‐invasive tool that quantifies intraocular blood flow. pilot study investigated whether LSFG metrics could be surrogates Additionally, we quantified flow the stenosed vessel before and after stenting usingsyngoiFlow (iFlow). Methods Fourteen patients had stents placed to treat symptomatic were obtained stenting. Mean blur rate (MBR), an index velocity, associated waveform parameters extracted from optic nerve head (ONH) region eye. iFlow time peak (TTP), cerebral contrast flow, by transforming digital subtraction angiography (DSA) images into perfusion heat maps.TTPswere seven regions interest (ROIs) two raters. Results Two significantly negatively correlated with These parameters, acceleration (FAI) rising (RR), also increased Intraclass correlation coefficients calculated TTPs showed substantial agreement across all ROIs. Significant decreases TTP observed ROIs high cervical ICA, cavernous segment brain parenchyma. Conclusions provides biometrics can accurately measure impact ICA quantifying Indices may serve surrogate sensitive quantify Non‐invasive flow‐dependent methods are promising assessment