Increased structural connectivity in high schizotypy

• DOI: 10.1162/netn_a_00279
• Publication Date: 2022-09-23T18:32:38Z
• Authors: Eirini Messaritaki; Sonya Foley; Kali Barawi; Ulrich Ettinger; Derek K. Jones
• Keywords: Parahippocampal gyrus; Postcentral gyrus; Middle frontal gyrus

The link between brain structural connectivity and schizotypy was explored in two healthy participant cohorts, collected at different neuroimaging centres, comprising 140 115 participants, respectively. participants completed the Schizotypal Personality Questionnaire (SPQ), through which their scores were calculated. Diffusion-MRI data used to perform tractography generate networks of participants. edges weighted with inverse radial diffusivity. Graph theoretical metrics default mode, sensorimotor, visual, auditory subnetworks derived correlation coefficients To best our knowledge, this is first time that graph measures are investigated relation schizotypy. A positive found score mean node degree clustering coefficient sensorimotor mode subnetworks. nodes driving these correlations right postcentral gyrus, left paracentral lobule, superior frontal parahippocampal bilateral precuneus, is, exhibit compromised functional schizophrenia. Implications for schizophrenia discussed.