Decreased surfactant dose-response after delayed administration to preterm rabbits.

• DOI: 10.1164/ajrccm.152.1.7599809
• Publication Date: 2013-04-04T21:53:15Z
• Authors: S R Seidner; M Ikegami; T Yamada; E D Rider; R Castro; A H Jobe
• Keywords: Lagomorpha

Preterm rabbits from 14 litters were delivered at 27 d gestation, anesthetized, and treated with surfactant birth, 15 min, or 30 min after the onset of mechanical ventilation. Doses ranging 0 to 100 mg/kg body weight given intratracheally ventilated for 45 birth. Pressure-volume curves dynamic compliances demonstrated that dose response progressively decreased delayed treatment. Following treatments 50 peak lung volumes 35 cm H2O increased by 49, 30, 8.4%, respectively over those untreated controls. Lung lavages receiving had significantly higher protein contents minimum surface tensions on Wilhelmy balance than birth (23.1 +/- 1.1 versus 16.0 2.7 dynes/cm), sections a less uniform distribution While increasing phospholipid concentrations may reverse inhibition serum proteins in vitro, there was progressive inability exogenous overcome this vivo following administration very immature rabbits. This associated its administration.