Pulmonary mechanics in dogs given different doses of kerosene intratracheally.

• DOI: 10.1164/arrd.1982.126.4.695
• Publication Date: 1982-10-01
• Authors: S M Scharf; Isebrand Prinsloo
• Keywords: Kerosene; Plethysmograph; Pulmonary compliance

Kerosene was instilled intratracheally into mongrel dogs of either sex weighing 10 to 15 kg and anesthetized intravenously with sodium pentobarbital (25 mg/kg). Two different doses were used: 0.3 0.06 ml/kg. Pulmonary mechanics, including pressure-volume (P-V) curve, thoracic gas volume (Vtg), total lung capacity (TLC), pulmonary resistance (RL), chord compliance (CL) measured by using a whole body plethysmograph, before at various time intervals during the 2 wk after instillation. Histologic studies also performed. In high-dose (0.3 ml/kg) kerosene experiments there significant decreases in Vtg, TLC, CL values 24 h, which returned control 1 The RL normalized for TLC did not change. contrast, receiving low dose (0.06 ml/kg), no change any these parameters h. examination revealed an early exudative phase consisting exudation macrophages, red cells, edema (at h), later proliferative bronchiolitis wk). Animals same pattern as those high but changes less extensive. We conclude (1) that kerosene-induced injury causes loss terminal air spaces both doses, (2) shift P-V curve is dependent. hypothesize two types physiologic lesions. areas remained open, increase occurred, whereas intraalveolar occurred "drop-out" units. final determined relative proportions areas.