Inspiratory Muscle Training in Patients with Chronic Obstructive Pulmonary Disease

• DOI: 10.1164/rccm.200202-075oc
• Publication Date: 2002-11-25T23:02:18Z
• Authors: Alba Ramírez-Sarm...; Mauricio Orozco-Levi; Rosa Güell; Esther Barreiro; Nuria Hernandez; Susana Mota; Merce Sangenis; Joan M. Broquetas; Pere Casan; Joaquim Gea
• Keywords: Muscles of respiration; Intercostal muscle

The present study was aimed at evaluating the effects of a specific inspiratory muscle training protocol on structure muscles in patients with chronic obstructive pulmonary disease. Fourteen (males, FEV1, 24 ± 7% predicted) were randomized to either or sham groups. Supervised breathing using threshold device performed 30 minutes per day, five times week, for 5 consecutive weeks. group subjected loading equivalent 40 50% their maximal pressure. Biopsies from external intercostal and vastus lateralis (control muscle) taken before after period. Muscle samples processed morphometric analyses monoclonal antibodies against myosin heavy chain isoforms I II. Increases both strength endurance observed group. This improvement associated increases proportion type fibers (by approximately 38%, p < 0.05) size II 21%, muscles. No changes control muscle. demonstrates that induces functional adaptive