Characterization of Cytokine/Chemokine Profiles of Severe Acute Respiratory Syndrome

• DOI: 10.1164/rccm.200407-857oc
• Publication Date: 2005-01-19T03:09:10Z
• Authors: Yong Jiang; Jun Xu; Chengzhi Zhou; Zhenguo Wu; Shuqing Zhong; Jinghua Liu; Wei Luo; Tao Chen; Qinghe Qin; Peng Deng
• Keywords: Monocyte; Macrophage inflammatory protein

There is currently no optimal treatment or effective drug for severe acute respiratory syndrome (SARS), because the immunopathologic mechanism poorly understood.To explore immune underlying pathogenesis of SARS, we studied expression profile cytokines/chemokines in blood and immunopathology lung lymphoid tissues.Fourteen 23 patients with SARS were dynamically screened, using a bead-based multiassay system. Reverse transcription-polymerase chain reaction was performed to amplify mRNA. Histopathology tissues at autopsy examined, methods immunohistochemistry double immunofluorescence staining.Interferon-inducible protein-10 (IP-10) markedly elevated during early stage remained high level until convalescence. Moreover, IP-10 highly expressed both tissues, where monocyte-macrophage infiltration depletion lymphocytes observed. The levels interleukin-6, interleukin-8, monocyte chemoattractant protein-1 concomitantly increased superinfection, mRNAs these cytokines also tissues.Induction critical event initiation immune-mediated injury lymphocyte apoptosis development SARS. Superinfection after main cause death. prompt elevation sign indicating risk