Transfusion-related Acute Lung Injury in the Critically Ill

• DOI: 10.1164/rccm.200702-271oc
• Publication Date: 2007-07-13T01:11:29Z
• Authors: Ognjen Gajic; Rimki Rana; Jeffrey L. Winters; Murat Yilmaz; Jose L. Mendez; Otis B. Rickman; Megan M. O'Byrne; Laura K. Evenson; Michael Malinchoc; Steven R. DeGoey; Bekele Afessa; Rolf D. Hubmayr; S. Breanndan Moore
• Keywords: Male; Respiratory Distress Syndrome; Time Factors; Critical Care; Incidence; Transfusion Reaction; Middle Aged; 3. Good health; Cohort Studies; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Risk Factors; Case-Control Studies; Humans; Blood Transfusion; Female; Aged

Acute lung injury (ALI) that develops 6 hours after transfusion (TRALI) is the leading cause of transfusion-related mortality. Several characteristics have been postulated as risk factors for TRALI, but evidence limited to retrospective studies.