Spirometry Centile Charts for Young Caucasian Children: The Asthma UK Collaborative Initiative

• DOI: 10.1164/rccm.200903-0323oc
• Publication Date: 2009-07-02T22:37:48Z
• Authors: S. Stanojevic; A. Wade; T. J. Cole; S. Lum; A. Custovic; M. Silverman; G. L. Hall; L. Welsh; J. Kirkby; W. Nystad; M. Badier; S. Davis; S. Turner; P. Piccioni; D. Vilozni; H. Eigen; H. Vlachos-Mayer; J. Zheng; W. Tomalak; M. Jones; J. L. Hankinson; J. Stocks
• Keywords: Severity of Illness Index; Asthma; United Kingdom; White People; Reference values; Respiratory Function Tests; 03 medical and health sciences; 0302 clinical medicine; Reference Values; Spirometry; Child, Preschool; Forced Expiratory Volume; Humans; Preschool; Child; Pulmonary function tests; Retrospective Studies

Advances in spirometry measurement techniques have made it possible to obtain measurements children as young 3 years of age; however, practice, application remains limited by the lack appropriate reference data for children, which are often based on population-specific samples.We aimed build previous models collating existing (aged 3-7 yr), produce updated prediction equations that span preschool and also linked established older adults.The Asthma UK Collaborative Initiative was collate lung function from healthy aged 7 years. Collaborators included researchers with access pulmonary test children. Spirometry centiles were created using LMS (lambda, micro, sigma) method extend previously published down age.The centile charts largest sample Caucasian (n = 3,777) 15 centers across 11 countries provide a continuous smooth transition into adolescence adulthood. These improve pediatric considering between-subject variability define more age-dependent lower limit normal. The collated set reflects variety equipment, protocols, population characteristics may be generalizable different populations.We present foundation will facilitate continued updating.