IL1RNCoding Variant Is Associated with Lower Risk of Acute Respiratory Distress Syndrome and Increased Plasma IL-1 Receptor Antagonist

• DOI: 10.1164/rccm.201208-1501oc
• Publication Date: 2013-03-01T19:42:47Z
• Authors: Nuala J. Meyer; Rui Feng; Mingyao Li; Yang Zhao; Chau-Chyun Sheu; Paula Tejera; Robert Gallop; Scarlett Bellamy; Melanie Rushefski; Paul N. Lanken; Richard Aplenc; Grant E. O’Keefe; Mark M. Wurfel; David C. Christiani; Jason D. Christie
• Keywords: Adult; Male; Risk; Respiratory Distress Syndrome; 0303 health sciences; Genotype; Receptors, Interleukin-1; Enzyme-Linked Immunosorbent Assay; Middle Aged; Polymorphism, Single Nucleotide; Severity of Illness Index; 3. Good health; Cohort Studies; Intensive Care Units; 03 medical and health sciences; Logistic Models; Risk Factors; Case-Control Studies; Humans; Female; Genetic Predisposition to Disease; Genetic Association Studies; Aged

Acute respiratory distress syndrome (ARDS) behaves as a complex genetic trait, yet knowledge of susceptibility factors remains incomplete.