Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus

• DOI: 10.1164/rccm.201412-2256oc
• Publication Date: 2015-03-02T16:37:29Z
• Authors: Maximillian S. Ha...; Agnieszka Jozwik; Spyridon Makris; Jake Dunning; Allan Paras; John P. DeVincenzo; Cornelis A. M. de...; Jens Wrammert; Peter J. M. Openshaw; Christopher Chiu
• Keywords: Convalescence; Memory B cell

Despite relative antigenic stability, respiratory syncytial virus (RSV) reinfects throughout life. After more than 40 years of research, no effective human vaccine exists and correlates protection remain poorly defined. Most current candidates seek to induce high levels RSV-specific serum neutralizing antibodies, which are associated with reduced RSV-related hospitalization rates in observational studies but may not actually prevent infection.