Association of Height Growth in Puberty with Lung Function. A Longitudinal Study

• DOI: 10.1164/rccm.201802-0274oc
• Publication Date: 2018-07-11T16:03:33Z
• Authors: Osama Mahmoud; Raquel Granell; Kate Tilling; Cosetta Minelli; Judith Garcia-Aym...; John W. Holloway; Adnan Custovic; Deborah Jarvis; Jonathan Sterne; John Henderson
• Keywords: Male; Adolescent; Respiratory System; Velocity of pubertal height growth; Growth; 333; MATURATION; DISEASE; MENARCHE; Young Adult; 03 medical and health sciences; AGE; 0302 clinical medicine; Critical Care Medicine; pubertal age; SuperImposition by Translation and Rotation; General & Internal Medicine; Humans; Longitudinal Studies; PREDICTORS; Child; Lung; 11 Medical and Health Sciences; velocity of pubertal height growth; RISK; CURVE; Science & Technology; Pubertal age; SITAR; Puberty; Avon Longitudinal Study of Parents and Children; ALSPAC; SPIROMETRY; CANCER; Body Height; Respiratory Function Tests; maximal lung function; Child, Preschool; Maximal lung function; GIRLS; Female; Life Sciences & Biomedicine

Rationale: Puberty may influence lung function, but the precise role of pubertal height growth in development is unclear.Objectives: To examine associations timing puberty and peak velocity with function adolescence early adulthood.Methods: Longitudinal analyses repeat measurements from age 5 to 20 years for a British birth cohort 4,772 males 4,849 females were conducted characterize trajectories derive using validated SITAR (SuperImposition by Translation Rotation) model. Association these estimates prebronchodilator post-bronchodilator spirometry measures: FEV1; FVC; FEV1/FVC; FEF25–75% at 15 24 investigated multivariable regression models adjusted 8 years, time outcome measurements, potential confounders.Measurements Main Results: Later greater associated higher FEV1 FVC both sexes. A 1-year increase was 263-ml (95% confidence interval [CI], 167–360 ml) (n = 567) 100-ml CI, 50–150 990). 1-cm/yr 145-ml 56–234 50-ml 2–99 increases females, respectively. No found FEV1/FVC.Conclusions: onset are increased young adults there no evidence dysanapsis growth.