Evidence for the Fucoidan/P-Selectin Axis as a Therapeutic Target in Hypoxia-induced Pulmonary Hypertension

• DOI: 10.1164/rccm.201806-1170oc
• Publication Date: 2018-12-17T23:41:03Z
• Authors: Tatyana Novoyatleva; Baktybek Kojonazarov; Andreas Owczarek; Swathi Veeroju; Nabham Rai; Ingrid Henneke; Mario Böhm; Friedrich Grimminger; Hossein A. Ghofrani; Werner Seeger; Norbert Weissmann; Ralph T. Schermuly
• Keywords: Fucoidan; Hypoxia

Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling and excessive proliferation of pulmonary artery smooth muscle cells (PASMCs). Fucoidan, a polysaccharidic ligand the adhesion molecule P-selectin, exhibits antiproliferative properties. The effects fucoidan/P-selectin axis on (PH) after hypoxia remain unexplored.