Inflammasome Activation: A Keystone of Proinflammatory Response in Obstructive Sleep Apnea

• DOI: 10.1164/rccm.202106-1445oc
• Publication Date: 2022-04-01T17:55:40Z
• Authors: Elena Díaz-García; Sara García-Tovar; Enrique Alfaro; Ana Jaureguizar; Raquel Casitas; Begoña Sánchez-Sá...; Ester Zamarrón; Juan Fernández-La...; Eduardo López-Col...; Carolina Cubillos...; Francisco García-Río
• Keywords: Proinflammatory cytokine; Intermittent hypoxia; Hypoxia; Pyroptosis

Rationale: As the mechanism that links obstructive sleep apnea (OSA) with regulation of inflammatory response is not well known, it important to understand inflammasome activation, mainly NLRP3 (nucleotide-binding oligomerization domain-like receptor 3). Objectives: To assess activity in patients severe OSA and identify its role systemic OSA. Methods: We analyzed as key components cascade, such adaptor molecule apoptosis-associated speck-like protein, caspase-1, Gasdermin D, IL-1β, IL-18, tissue factor, monocytes plasma from control subjects without apnea. explored association different markers comorbidities. Measurements Main Results: Monocytes presented higher than those subjects, which directly correlated apnea-hypopnea index hypoxemic indices. overactivity triggered cytokines (IL-1β IL-18) via caspase-1 increased allowing for factor be released. In vitro models confirmed increase signaling under intermittent hypoxia a hypoxia-inducible factor-1α-dependent manner, and/or combination Plasma concentrations were comorbidities them. Conclusions: OSA, activation might linking between other OSA-induced immediate changes development response.