Development of a Blood-based Transcriptional Risk Score for Chronic Obstructive Pulmonary Disease

• DOI: 10.1164/rccm.202107-1584oc
• Publication Date: 2021-11-05T20:22:16Z
• Authors: Matthew Moll; Adel Boueiz; Auyon J. Ghosh; Aabida Saferali; Sool Lee; Zhonghui Xu; Jeong H. Yun; Brian D. Hobbs; Craig P. Hersh; Don D. Sin; Ruth Tal-Singer; Edwin K. Silverman; Michael H. Cho; Peter J. Castaldi; James D. Crapo; Edwin K. Silverman; Barry J. Make; Elizabeth A. Regan; Terri Beaty; Ferdouse Begum; Peter J. Castaldi; Michael Cho; Dawn L. DeMeo; Adel R. Boueiz; Marilyn G. Foreman; Eitan Halper-Stro...; Lystra P. Hayden; Craig P. Hersh; Jacqueline Hetmanski; Brian D. Hobbs; John E. Hokanson; Nan Laird; Christoph Lange; Sharon M. Lutz; Merry-Lynn McDonald; Margaret M. Parker; Dmitry Prokopenko; Dandi Qiao; Phuwanat Sakornsa...; Edwin K. Silverman; Emily S. Wan; Juan Pablo Centeno; Jean-Paul Charbon...; Harvey O. Coxson; Craig J. Galban; MeiLan K. Han; Eric A. Hoffman; Stephen Humphries; Francine L. Jacobson; Philip F. Judy; Ella A. Kazerooni; Alex Kluiber; David A. Lynch; Pietro Nardelli; John D. Newell; Aleena Notary; Andrea Oh; James C. Ross; Raul San Jose Est...; Joyce Schroeder; Jered Sieren; Berend C. Stoel; Juerg Tschirren; Edwin Van Beek; Bram van Ginneken; Eva van Rikxoort; Gonzalo Vegas San...; Lucas Veitel; George R. Washko; Carla G. Wilson; Robert Jensen; Douglas Everett; Jim Crooks; Katherine Pratte; Matt Strand; Gregory Kinney; Sharon M. Lutz; Kendra A. Young; Surya P. Bhatt; Jessica Bon; Alejandro A. Diaz; Susan Murray; Xavier Soler; Russell P. Bowler; Katerina Kechris; Farnoush Banaei-K...
• Keywords: Male; Multifactorial Inheritance; Middle Aged; Risk Assessment; Severity of Illness Index; 3. Good health; Pulmonary Disease, Chronic Obstructive; 03 medical and health sciences; Phenotype; 0302 clinical medicine; Gene Expression Regulation; Predictive Value of Tests; Risk Factors; Disease Progression; Odds Ratio; Humans; Female; Genetic Predisposition to Disease; Prospective Studies; Biomarkers; Aged; Transcription Factors

The ability of peripheral blood biomarkers to assess chronic obstructive pulmonary disease (COPD) risk and progression is unknown. Genetics gene expression may capture important aspects COPD-related biology that predict activity.