Increased SARS-CoV-2 Infection, Protease, and Inflammatory Responses in Chronic Obstructive Pulmonary Disease Primary Bronchial Epithelial Cells Defined with Single-Cell RNA Sequencing

• DOI: 10.1164/rccm.202108-1901oc
• Publication Date: 2022-05-12T17:51:37Z
• Authors: Matt D. Johansen; Rashad M. Mahbub; Sobia Idrees; Duc H. Nguyen; Stefan Miemczyk; Prabuddha Pathina...; Kristy Nichol; Nicole G. Hansbro; Linden J. Gearing; Paul J. Hertzog; David Gallego-Ortega; Warwick J. Britton; Bernadette M. Sau...; Peter A. Wark; Alen Faiz; Philip M. Hansbro
• Keywords: Proinflammatory cytokine

Patients with chronic obstructive pulmonary disease (COPD) develop more severe coronavirus (COVID-19); however, it is unclear whether they are susceptible to acute respiratory syndrome 2 (SARS-CoV-2) infection and what mechanisms responsible for disease.