PCSK6 and Survival in Idiopathic Pulmonary Fibrosis

• DOI: 10.1164/rccm.202205-0845oc
• Publication Date: 2023-02-13T21:47:07Z
• Authors: Justin M. Oldham; Richard J. Allen; Jose M. Lorenzo-S...; Philip L. Molyneaux; Shwu-Fan Ma; Chitra Joseph; John S. Kim; Beatriz Guillen-Guio; Tamara Hernández-...; Jonathan A. Kropski; Yong Huang; Cathryn T. Lee; Ayodeji Adegunsoye; Janelle Vu Pugash...; Angela L. Linderholm; Vivian Vo; Mary E. Strek; Jonathan Jou; Adrian Muñoz-Barrera; Luis A. Rubio-Rod...; Richard Hubbard; Nik Hirani; Moira K. B. Whyte; Simon Hart; Andrew G. Nicholson; Lisa Lancaster; Helen Parfrey; Doris Rassl; William Wallace; Eleanor Valenzi; Yingze Zhang; Josyf Mychaleckyj; Amy Stockwell; Naftali Kaminski; Paul J. Wolters; Maria Molina-Molina; Nicholas E. Banovich; William A. Fahy; Fernando J. Martinez; Ian P. Hall; Martin D. Tobin; Toby M. Maher; Timothy S. Blackwell; Brian L. Yaspan; R. Gisli Jenkins; Carlos Flores; Louise V. Wain; Imre Noth
• Keywords: Survival; Clinical Sciences; Respiratory System; Genome-wide Association Study; PCSK6 protein; Clinical sciences; Autoimmune Disease; survival; Medical and Health Sciences; Cardiovascular medicine and haematology; Pulmonary fibrosis; Rare Diseases; Cardiovascular Medicine and Haematology; PCSK6; genomics; Genetics; 2.1 Biological and endogenous factors; Humans; Lung; Proportional Hazards Models; genome-wide association study; Biomedical and Clinical Sciences; Protein; Human Genome; Serine Endopeptidases; Fibrosi pulmonar; Original Articles; Idiopathic Pulmonary Fibrosis; 3. Good health; Europe; Good Health and Well Being; IPF; Respiratory; Proprotein Convertases; Genètica; Genome-Wide Association Study

Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by limited treatment options and high mortality. A better understanding of the molecular drivers IPF progression needed.