Design and Development of Amphotericin B Bearing Polycaprolactone Microparticles for Macrophage Targeting

• DOI: 10.1166/jbn.2011.1196
• Publication Date: 2011-02-11T04:57:34Z
• Authors: Pankaj Singh; Amit Gupta; Anil Jaiswal; Anuradha Dube; Saurabh Mishra; ManishK. Chaurasia
• Keywords: Leishmania; Mesocricetus; Drug Compounding; Macrophages; Antiprotozoal Agents; 02 engineering and technology; Survival Rate; Nanocapsules; Amphotericin B; Cricetinae; Drug Design; Animals; 0210 nano-technology

Antileishmanial efficacy of Amphotericin B bearing polycaprolactone (PCL) microparticles was investigated. The microparticles were prepared, optimized and subjected to in vitro characterization for shape (spherically structured), particle size (9.83 +/- 1.12 microm), entrapment efficiency (43.54 +/- 3.98%) and in vitro drug release. The study revealed that PCL microparticles bearing Amphotericin B can be effectively used to target leishmanial parasites residing in macrophages.