Effect of Memantine Hydrochloride on Homocysteine Level and Cognitive Function in Diabetic Vascular Dementia Model Mice

• DOI: 10.1166/jbt.2021.2643
• Publication Date: 2021-06-21T11:23:27Z
• Authors: Yu Yang; Lifei Xing; Hongliang Yan; Min Wang; Yanqing Huang; Meiping Zhao; Haiying Wang; Yanhong Wang
• Keywords: Vascular dementia; Memantine

Increased Hcy has a toxic effect on nerve cells and can cause hippocampal death directly damage the body’s cognitive function memory ability, leading to occurrence of vascular dementia. predicts disease might be basis for clinical judgment. This article provides new prevention treatment this by exploring mechanism action memantine hydrochloride in diabetic After grouping, mice walked through Morris water maze record escape latency, measured level high performance liquid chromatography. Observing volume brain atrophy mice. GFAPT, APP, CHAT mouse hippocampus was assessed IHC mRNA detected RT-PCR. Escape (11.46 ±0.74) yiimmol/L, (25.21 ±1.21) mm 3 , number APP positive (46.7003±3.2431), GFAP (21.4000 ± 1.8127) were all significantly lower than those model group. The rate amount group elevated ( P < 0.05) with higher blank 0.05). Memantine could reduce mice, improve dementia improving cortex, increasing tissue.