Rice Bran Extract Inhibits TMEM16A-Involved Activity in the Neonatal Rat Cochlea

• DOI: 10.1166/jnn.2017.13333
• Publication Date: 2017-02-22T03:03:24Z
• Authors: Kushal Sharma; Jiwon Sung; Hyun-Jung Kim; Min-Ho Oak; Eunyoung Yi
• Keywords: Dietary Fiber; 0301 basic medicine; Plant Extracts; Antineoplastic Agents; Oryza; Cochlea; Rats; 3. Good health; Rats, Sprague-Dawley; 03 medical and health sciences; Animals, Newborn; Cell Line, Tumor; Animals; Anoctamin-1

TMEM16A is a Ca²⁺-activated Cl⁻ channel found in secretory glands, GI and respiratory tracts, sensory organs, playing major physiological role fluid secretion, autonomous motility, transduction. In addition, overexpression of has been associated with cancer cell proliferation invasion. Suppression upregulated proposed as an effective anti-cancer strategy. While searching for potential inhibitor, components rice bran attracted our attention due to their colon cells, type cells known overexpressing TMEM16A. Here, it was tested whether extract exhibits anti-TMEM16A activity. Rice the neonatal rat cochlear tissues where TMEM16A-involved spontaneous activity generated part normal development auditory pathway. readily inhibited effect reversible upon washout. Taken together, appears contain putative inhibitor byproduct might serve source new agent.