Microperimetry Reliability Assessed From Fixation Performance

• DOI: 10.1167/tvst.12.5.21
• Publication Date: 2023-05-23T15:02:32Z
• Authors: Amandeep Singh Josan; Isabella Farrance; Laura J. Taylor; Daniel Adeyoju; Thomas M. W. Buckley; Jasleen K. Jolly; Robert E. MacLaren
• Keywords: Microperimetry; Central scotoma; Stargardt disease; Fundus (uterus)

Purpose: Microperimetry provides an accurate assessment of central retinal sensitivity due to its fundus-tracking capability, but it has limited reliability indicators. One method currently employed, fixation loss, samples the optic nerve blind spot for positive responses; however, is unclear if these responses arise from unintentional button presses or tracking failure leading stimuli misplacement. We investigated relationship between scotoma (termed responses) and fixation. Methods: Part 1 study involved a custom grid 181 points centered on that was constructed map physiological spots in primary simulated eccentric positions. Scotoma 63% 95% bivariate contour ellipse areas (BCEA63 BCEA95) were analyzed. In 2, data controls patients with diseases (234 eyes 118 patients) collected. Results: 1, linear mixed model 32 control participants, demonstrated significant (P < 0.001) correlation BCEA95. upper confidence intervals BCEA95 3.7 deg2 controls, 27.6 choroideremia, 23.1 typical rod–cone dystrophies, 21.4 Stargardt disease, 111.3 age-related macular degeneration. Incorporating all pathology groups into overall statistic resulted limit = 29.6 deg2. Conclusions: significantly correlated performance, surrogate marker test accuracy. Examinations healthy individuals disease are deemed unreliable > 4 30 deg2, respectively. Translational Relevance: should be assessed using performance as summarized by rather than level losses.