Diagnostic Performance of Macular Versus Peripapillary Vessel Parameters by Optical Coherence Tomography Angiography for Glaucoma

• DOI: 10.1167/tvst.7.6.21
• Publication Date: 2018-12-06T22:33:18Z
• Authors: Grace M. Richter; Ryuna Chang; Betty Situ; Zhongdi Chu; Bruce Burkemper; Alena Reznik; Sahar Bedrood; Amir H. Kashani; Rohit Varma; Ruikang K. Wang
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Articles

To compare the diagnostic ability of vessel parameters in macular and peripapillary regions measured using spectral-domain optical coherence tomography angiography (SD-OCTA) differentiating primary open-angle glaucoma (POAG) from healthy eyes.POAG patients subjects underwent 6 × 6-mm scans centered on macula optic nerve head. Commercially available automatic segmentation created en face images SD-OCTA superficial retinal layer (SRL) (m) (cp) regions. Vessel area density (VAD), skeleton (VSD), complexity index (VCI), flux were calculated. Area under curve (AUC) statistics controlled for age intereye correlation.Of 126 eyes 79 who imaging, 50 35 POAG 37 25 control had good quality imaging studied. Diagnostic accuracies four perfusion parameters, VAD, VSD, VCI, flux, significantly greater compared with For cpAUC was 0.84 mAUC 0.73 (AUC difference: P = 0.026). 0.72 (ΔP 0.015). 0.80 0.70 0.045). 0.87 0.76 0.0091).Peripapillary performed better than diagnosis, supporting idea that glaucomatous vascular changes are more pronounced region.The accuracy OCTA microcirculation region diagnosis glaucoma.