Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury

• DOI: 10.1172/jci.insight.120196
• Publication Date: 2018-09-05T15:02:36Z
• Authors: Wai Yan Sun; Bo Bai; Cuiting Luo; Kangmin Yang; Dahui Li; Donghai Wu; Michel Félétou; Nicole Villeneuve; Yang Zhou; Junwei Yang; Aimin Xu; Paul M. Vanhoutte; Yu Wang
• Keywords: Renal Injury

Lipocalin-2 is not only a sensitive biomarker, but it also contributes to the pathogenesis of renal injuries. The present study demonstrates that adipose tissue–derived lipocalin-2 plays critical role in causing both chronic and acute Four-week treatment with aldosterone high salt after uninephrectomy (ANS) significantly increased circulating urinary lipocalin-2, induced glomerular tubular injuries kidneys WT mice. Despite expression lcn2 excretion mice selective deletion alleles tissue (Adipo-LKO) are protected from ANS- or aldosterone-induced By contrast, kidney did prevent aldosterone- ANS-induced Transplantation fat pads donors sensitivity complete Lcn2 (LKO) Aldosterone promoted human variant, R81E, turn LKO Chronic R81E triggered significant LKO, resembling those observed following ANS challenge. Taken conjunction, results demonstrate derived causes injuries, largely independent local kidney.