Distinct amino acid and lipid perturbations characterize acute versus chronic malaria

• DOI: 10.1172/jci.insight.125156
• Publication Date: 2019-05-01T15:01:25Z
• Authors: Regina Joice Cordy; Rapatbhorn Patrap...; Loukia N. Lili; Monica Cabrera-Mora; Jung-Ting Chien; Gregory K. Tharp; Manoj Khadka; Esmeralda V.S. Meyer; Stacey A. Lapp; Chester J. Joyner; AnaPatricia Garcia; Sophia Banton; ViLinh Tran; Viravarn Luvira; Siriwan Rungin; Teerawat Saeseu; Nattawan Rachaphaew; Suman B. Pakala; Jeremy D. DeBarry; Jessica C. Kissinger; Eric A. Ortlund; Steven E. Bosinger; John W. Barnwell; Dean P. Jones; Karan Uppal; Shuzhao Li; Jetsumon Sattabon...; Alberto Moreno; Mary R. Galinski
• Keywords: Plasmodium (life cycle); Pathogenesis; Chronic infection

Chronic malaria is a major public health problem and significant challenge for disease eradication efforts. Despite its importance, the biological factors underpinning chronic are not fully understood. Recent studies have shown that host metabolic state can influence pathogenesis transmission, but role in chronicity known. Here, with goal of identifying distinct modifications metabolite profiles acute versus malaria, metabolomics was performed on plasma from Plasmodium-infected humans nonhuman primates range parasitemias clinical signs. In rhesus macaques infected Plasmodium coatneyi, alterations amines, carnitines, lipids were detected during high parasitemic phase many these reverted to baseline levels once low established. gene expression, studied parallel macaques, revealed transcriptional changes amine, fatty acid, lipid energy metabolism genes, as well variant antigen genes. Furthermore, common set distinguished human falciparum cases. summary, host-parasite environments been uncovered characterize providing insights into underlying biology progression.