Predictability of individual circadian phase during daily routine for medical applications of circadian clocks

• DOI: 10.1172/jci.insight.130423
• Publication Date: 2019-08-20T16:00:37Z
• Authors: Sandra Komarzynski; Matei Bolborea; Qi Huang; Bärbel Finkenstädt; Francis Lévi
• Keywords: Chronotype; Tolerability; Chronotherapy (sleep phase); Predictability; Clockwork; Chronobiology; Phase response curve

BACKGROUND. Circadian timing of treatments can largely improve tolerability and efficacy in patients. Thus, drug metabolism cell cycle are controlled by molecular clocks each coordinated the core body temperature 24-hour rhythm, which is generated hypothalamic pacemaker. Individual circadian phase currently estimated with questionnaire-based chronotype, center-of-rest time, dim light melatonin onset (DLMO), or (CBT) maximum (acrophase) minimum (bathyphase).