IL-33 activates group 2 innate lymphoid cell expansion and modulates endometriosis

• DOI: 10.1172/jci.insight.149699
• Publication Date: 2021-10-26T16:01:20Z
• Authors: Jessica E. Miller; Harshavardhan Lin...; Lindsey K. Symons; Olga Bougie; Steven L. Young; Bruce A. Lessey; Madhuri Koti; Chandrakant Tayade
• Keywords: Innate lymphoid cell; Interleukin 33; Pathophysiology

Chronic inflammation and localized alterations in immune cell function are suspected to contribute the progression of endometriosis its associated symptoms. In particular, alarmin IL-33 is elevated plasma, peritoneal fluid, endometriotic lesions from patients with endometriosis; however, exact role pathophysiology not well understood. this study, we demonstrate, both humans a murine model, that contributes expansion group 2 innate lymphoid cells (ILC2s), IL-33-induced ILC2 modulates lesion microenvironment. Importantly, show drives hallmarks severe endometriosis, including inflammation, proliferation, fibrosis, aggravation mediated by ILC2s. Finally, demonstrate functionality neutralization as promising potentially novel therapeutic avenue for treating debilitating symptoms endometriosis.