Microbiota dynamics in a randomized trial of gut decontamination during allogeneic hematopoietic cell transplantation

• DOI: 10.1172/jci.insight.154344
• Publication Date: 2022-03-03T17:00:47Z
• Authors: Christopher J. Se...; Benjamin A. Siran...; Sandra Tian-Jiao ...; Angel Moreno; Michelle M. Li; Nan Chen; Christine N. Duncan; Steven P. Margossian; Leslie E. Lehmann; Shan Sun; Tessa M. Andermann; Olga Birbrayer; Sophie Silverstein; Carol G. Reynolds; Soomin Kim; Niaz Banaei; Jerome Ritz; Anthony A. Fodor; Wendy B. London; Ami S. Bhatt; Jennifer S. Whangbo
• Keywords: Gut microbiome; Human decontamination

BACKGROUND. Gut decontamination (GD) can decrease the incidence and severity of acute graft-versus-host disease (aGVHD) in murine models allogeneic hematopoietic cell transplantation (HCT). In this pilot study, we examined impact GD on gut microbiome composition aGVHD HCT patients.