CXCL13-producing CD4+ T cells accumulate in the early phase of tertiary lymphoid structures in ovarian cancer

• DOI: 10.1172/jci.insight.157215
• Publication Date: 2022-05-12T16:00:48Z
• Authors: Masayo Ukita; Junzo Hamanishi; Hiroyuki Yoshitomi; Koji Yamanoi; Shiro Takamatsu; Akihiko Ueda; Haruka Suzuki; Yuko Hosoe; Yoko Furutake; Mana Taki; Kaoru Abiko; Ken Yamaguchi; Hidekatsu Nakai; Tsukasa Baba; Noriomi Matsumura; Akihiko Yoshizawa; Hideki Ueno; Masaki Mandai
• Keywords: CXCL13; Infiltration (HVAC); Tumor-infiltrating lymphocytes

Tertiary lymphoid structures (TLS) are transient ectopic aggregates whose formation might be caused by chronic inflammation states, such as cancer. However, how TLS induced in the tumor microenvironment (TME) and they affect patient survival not well understood. We investigated distribution relation to infiltrating lymphocytes (TILs) related gene expression high-grade serous ovarian cancer (HGSC) specimens. CXCL13 correlated with presence infiltration of T cells B cells, it was a favorable prognostic factor for patients HGSC. Coexistence CD8+ cell lineages TME significantly improved prognosis HGSC TLS. predominantly coincident CD4+ TILs, shifted from CD21+ follicular DCs matured. In mouse model, recombinant enhanced cells. These results suggest that associated CXCL13-producing facilitated coordinated antitumor response cellular humoral immunity