Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people

• DOI: 10.1172/jci.insight.161045
• Publication Date: 2022-08-09T16:01:41Z
• Authors: Joana Vitallé; Alberto Pérez-Gómez; Francisco José Ostos; Carmen Gasca-Capote; María Reyes Jimén...; Sara Bachiller; Inmaculada Rivas-...; Maria del Mar Sil...; Anabel M. Ruiz-Ma...; María Ángeles Mar...; Luis Fernando Lóp...; Mohammed Rafii-El...; Ezequiel Ruiz-Mateos
• Keywords: 2019-20 coronavirus outbreak

The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are mostly unknown. We studied individuals older than 60 and younger years, who had been vaccinated BNT162b2 mRNA, before after the first second dose. Aging was a lower anti–RBD IgG levels decreased magnitude polyfunctionality of SARS-CoV-2–specific T cell response. dramatic decrease thymic function > which fueled alteration homeostasis, their CD161+ were 2 months vaccination. Additionally, deficient DC homing, activation, TLR-mediated function, along proinflammatory functional profile monocytes, observed 60-year-old group, also related to specific These findings might be relevant for improvement current vaccination strategies development new prototypes.