Age-related dysregulation of intestinal epithelium fucosylation is linked to an increased risk of colon cancer

• DOI: 10.1172/jci.insight.167676
• Publication Date: 2024-02-05T14:16:51Z
• Authors: Zhihan Wang; Pan Gao; Kai Guo; Grace Schirrick; Jappreet Singh Gill; Jett Weis; Abby Lund Da Costa; Mansib Rahman; Het Mehta; Julia Fleecs; Shilpi Jain; Trishna Debnath; Junguk Hur; Nadeem Khan; Robert Sticca; Holly M. Brown-Borg; Donald A. Jurivich; Ramkumar Mathur
• Keywords: Fucosylation; Dysbiosis; Intestinal epithelium

Colon cancer affects people of all ages. However, its frequency, as well the related morbidity and mortality, are high among older adults. The complex physiological changes in aging gut substantially limit development therapies. Here, we identify a unique intestinal microenvironment that is linked with an increased risk colon Our findings show markedly influences persistent fucosylation apical surfaces epithelial cells, which results favorable environment for tumor growth. Furthermore, our shed light on importance host-commensal interaction, facilitates dysregulation promotes growth get older. We analyzed colonic microbial populations at species level to find associated could contribute cancer. Analysis scRNAseq from previous publication datasets identifies distinct cell subtypes involved dysregulated Overall, study provides compelling evidence excessive cancer, age-related increase vulnerability dysbiosis diversity metabolic homeostasis mice dysregulate levels age.