Eosinophils restrain humoral alloimmunity after lung transplantation

• DOI: 10.1172/jci.insight.168911
• Publication Date: 2024-02-14T13:43:21Z
• Authors: Zhongcheng Mei; May A. Khalil; Yizhan Guo; Dongge Li; Anirban Banerjee; Yuriko Terada; Yuhei Yokoyama; Christina Kratzmeier; Kelly Chen; Lushen Li; Christine L. Lau; Jean-Paul Courneya; Irina G. Luzina; Sergei P. Atamas; Andrew E. Gelman; Daniel Kreisel; Elizabeth A. Jaco...; Alexander S. Krup...
• Keywords: Alloimmunity; CXCR5

While the function of many leukocytes in transplant biology has been well defined, role eosinophils is controversial and remains poorly explored. Conflicting data exist regarding eosinophils' alloimmunity. Due to their prevalence lung, defined other pulmonary pathologies such as asthma, we set out explore long-term maintenance lung allograft. We noted that depletion results generation donor-specific antibodies. Eosinophil increased memory B cell, plasma antibody-secreting cell differentiation resulted de novo follicular germinal centers. Germinal center formation depended on expansion CD4+Foxp3–Bcl6+CXCR5+PD-1+ T helper (Tfh) cells, which increase number after eosinophil depletion. Mechanistically, demonstrate prevent Tfh by acting dominant source IFN-γ an established allograft, thus facilitating Th1 rather than polarization naive CD4+ cells. Our describe what believe a unique previously unknown for maintaining allograft tolerance suggest indiscriminate administration eosinophil-lytic corticosteroids treatment acute cellular rejection may inadvertently promote humoral