Insulin’s direct hepatic effect explains the inhibition of glucose production caused by insulin secretion

• DOI: 10.1172/jci.insight.91863
• Publication Date: 2017-03-22T15:01:42Z
• Authors: Dale S. Edgerton; Guillaume Kraft; Marta Smith; Ben Farmer; Phillip E. Williams; Katie C. Coate; Richard L. Printz; Richard M. O’Brien; Alan D. Cherrington
• Keywords: Insulin oscillation; Hyperinsulinemia; Basal (medicine)

Insulin can inhibit hepatic glucose production (HGP) by acting directly on the liver as well indirectly through effects adipose tissue, pancreas, and brain. While insulin's indirect are indisputable, their physiologic role in suppression of HGP seen response to increased insulin secretion is not clear. Likewise, mechanisms which suppresses lipolysis pancreatic α cell under circumstances also debated. In this study, was infused into portal vein mimic secretion, were blocked either individually or collectively. During hyperinsulinemia, plasma free fatty acid (FFA) glucagon levels clamped at basal values brain action blocked, but direct left intact. equally effective suppressing when its absent they present. addition, inhibition lipolysis, did require CNS decreased FFA. This indicates that rapid attributable effect redundant context a increase secretion.