Correction of intermittent hypoxia reduces inflammation in obese subjects with obstructive sleep apnea

• DOI: 10.1172/jci.insight.94379
• Publication Date: 2017-09-06T21:27:40Z
• Authors: Sebastio Perrini; Angelo Cignarelli; Vitaliano Nicola ...; Vito Antonio Falcone; Stella Kounaki; Stefania Porro; Alessandro Ciavar...; Romina Ficarella; Maria Barbaro; Valentina Annamar...; Pasquale Nigro; Pierluigi Carratù; Annalisa Natalicchio; Luigi Laviola; Onofrio Resta; Francesco Giorgino
• Keywords: Hypoxia

In obese subjects with obstructive sleep apnea (OSA), chronic intermittent hypoxia (CIH) may be linked to systemic and adipose tissue inflammation.We obtained abdominal subcutaneous biopsies from OSA non-OSA (BMI > 35) at baseline after 24 weeks (T1) of weight-loss intervention plus continuous positive airway pressure (c-PAP) or alone, respectively. were grouped according good (therapeutic) poor (subtherapeutic) adherence c-PAP.At baseline, anthropometric metabolic parameters, serum cytokines, mRNA levels obesity-associated chemokines inflammatory markers not different in subjects. At T1, body weight was significantly reduced all groups. Serum concentrations IL-2, IL-4, IL-6, MCP-1, PDGFβ, VEGFα by therapeutic c-PAP remained unaltered subtherapeutic Similarly, macrophage-specific (CD68, CD36) ER stress (ATF4, CHOP, ERO-1) gene markers, as well VEGFα, decreased only the group.CIH does represent an additional factor increasing inflammation morbid obesity. However, OSA, effective therapy improves markers.Ministero dell'Università e della Ricerca Progetti di Rilevante Interesse Nazionale.