Reevaluation of immune activation in the era of cART and an aging HIV-infected population

• DOI: 10.1172/jci.insight.95726
• Publication Date: 2017-10-18T15:00:36Z
• Authors: Lesley R. de Armas; Suresh Pallikkuth; Varghese George; Stefano Rinaldi; Rajendra Pahwa; Kristopher L. Arh...; Savita Pahwa
• Keywords: Cart; Immunosenescence; Senescence

Biological aging is associated with immune activation (IA) and declining immunity due to systemic inflammation. It widely accepted that HIV infection causes persistent IA premature senescence despite effective antiretroviral therapy virologic suppression; however, the effects of combined are not well defined. Here, we assessed relationship between markers inflammation during biological in HIV-infected -uninfected populations. Antibody response seasonal influenza vaccination was implemented as a measure competence relationships IA, inflammation, antibody responses were explored using statistical modeling appropriate for integrating high-dimensional data sets. Our results show such coexpression HLA antigen D related (HLA-DR) CD38 on CD4+ T cells, exhibit strong associations but age. Certain variables showed aging, naive CD38+ CD4 CD8+ did so regardless infection. Interestingly, variable age identified predictive model significantly impacting vaccine either group, while distinct inflammatory closely These findings shed light most relevant defects virological suppression therapy.