Proton Magnetic Resonance Spectroscopy of Bipolar Disorder Versus Intermittent Explosive Disorder in Children and Adolescents

• DOI: 10.1176/appi.ajp.160.8.1442
• Publication Date: 2003-08-04T17:35:14Z
• Authors: Pablo Davanzo; Kenneth Yue; M. Albert Thomas; Thomas Belin; Jim Mintz; T.N. Venkatraman; Eliana Santoro; Sarah Barnett; James McCracken
• Keywords: Creatine

OBJECTIVE: The diagnosis of bipolar disorder in juveniles is controversial. This study was designed to compare proton magnetic resonance spectroscopy (1H MRS) patients with or intermittent explosive disorder, two groups symptomatic overlap but categorical distinction. Children designate whose illness clinically resembles pediatric does not satisfy DSM-IV criteria for mania. Based on the authors' previous report higher levels 1H MRS cingulate myo-inositol/creatine youngsters than normal comparison subjects, they hypothesized that would have myo-inositol/creatine-phosphocreatine measurements and subjects. METHOD: Myo-inositol were measured a 2×2×2 cm3 voxel placed anterior acquisition 10 13 N-Acetylaspartate, choline moieties, creatine-phosphocreatine, glutamate-glutamine metabolite also measured. RESULTS: showed significantly myo-inositol (mmol/liter) No significant differences found across other metabolites occipital cortex. CONCLUSIONS: These data provide evidence concentration cortex may differentiate these populations. Follow-up studies involving larger samples conclusively estimate biological specificity between disorders, which clinically.