Randomized, Placebo-Controlled Trial of Mixed Amphetamine Salts for Symptoms of Comorbid ADHD in Pediatric Bipolar Disorder After Mood Stabilization With Divalproex Sodium

• DOI: 10.1176/appi.ajp.162.1.58
• Publication Date: 2004-12-30T01:58:53Z
• Authors: Russell E. Scheffer; Robert A. Kowatch; Thomas Carmody; A. John Rush
• Keywords: Divalproex; Dextroamphetamine

The purpose of this study was to determine whether adjunctive use a psychostimulant (mixed amphetamine salts) safe and efficacious for treatment symptoms attention deficit hyperactivity disorder (ADHD) in pediatric outpatients with bipolar I or II concurrent ADHD whose manic had been stabilized through divalproex sodium.An 8-week open-label trial sodium control discern the effect on followed by 4-week randomized, double-blind, placebo-controlled crossover if mixed salts effective symptoms. Patients continued receive sodium. Diagnoses, made clinical interview, were confirmed Washington University St. Louis Kiddie Schedule Affective Disorders Schizophrenia. Young Mania Rating Scale (for symptoms) Clinical Global Impression improvement primary outcome measures.Forty subjects ages 6-17 years (77.5%) (22.5%) score > =14 entered open With sodium, 32 achieved =50% reduction baseline scores, but only three participants significant For 30 who trial, significantly more than placebo No side effects worsening observed.Pediatric patients can be safely effectively treated after their are Divalproex alone (8-week trial) is not an context disorder.