Presupplementary Motor Area Hyperactivity During Response Inhibition: A Candidate Endophenotype of Obsessive-Compulsive Disorder

• DOI: 10.1176/appi.ajp.2012.12010073
• Publication Date: 2012-10-02T15:21:20Z
• Authors: Stella J. de Wit; Froukje E. de Vries; Ysbrand D. van de...; Danielle C. Cath; Dirk J. Heslenfeld; Eveline M. Veltman; Anton J.L.M. van ...; Dick J. Veltman; Odile A. van den ...
• Keywords: Endophenotype; Stop signal; Neurocognitive; Inferior frontal gyrus; Parietal lobe; Supplementary motor area

Objective Endophenotype studies of obsessive-compulsive disorder (OCD) may uncover heritable traits that are related to genetic susceptibility OCD. Deficient response inhibition is a promising endophenotype OCD, although its functional neural correlates have not been extensively studied. The authors sought determine the in large sample medication-free OCD patients and their unaffected siblings. Method Forty-one patients, 17 siblings, 37 matched healthy comparison subjects performed stop-signal task during 3-T MRI. reaction time provided behavioral measure inhibition. were assessed region-of-interest analysis included presupplementary motor area, inferior frontal gyrus, subthalamic nucleus, parietal cortex. Results Patients with had greater times relative subjects. numerical difference between siblings failed reach significance. Both showed activity left area successful Relative both decreased right cortex gyrus. In correlated negatively time. Conclusions These findings suggest hyperactivity neurocognitive possibly inefficient processing within itself. further state-dependent deficit recruiting which contribute deficit.