The Role of Intrinsic Brain Functional Connectivity in Vulnerability and Resilience to Bipolar Disorder

• DOI: 10.1176/appi.ajp.2017.17010095
• Publication Date: 2017-08-18T07:01:12Z
• Authors: Gaelle E. Doucet; Danielle S. Bassett; Nailin Yao; David C. Glahn; Sophia Frangou
• Keywords: Group cohesiveness

Bipolar disorder is a heritable characterized by mood dysregulation associated with brain functional dysconnectivity. Previous research has focused on the detection of risk- and disease-associated dysconnectivity in individuals bipolar their first-degree relatives. The present study seeks to identify adaptive connectivity features resilience, defined here as avoidance illness or delayed onset unaffected siblings patients disorder.Graph theoretical methods were used examine global regional network topology head-motion-corrected resting-state MRI data acquired from 78 disorder, 64 siblings, 41 healthy volunteers.Global properties preserved while both groups showed reductions cohesiveness sensorimotor network. In patient group, these abnormalities coupled reduced integration core default mode regions ventromedial cortex hippocampus. Conversely, was increased sibling group compared volunteer group.The authors found that trait-related vulnerability disorder. However, emerged key feature differentiating disease expression resilience between siblings. This indicative presence neural mechanisms may promote at least delay onset.