Long-Term Outcomes of Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Depression

• DOI: 10.1176/appi.ajp.2019.18121427
• Publication Date: 2019-10-04T07:01:04Z
• Authors: Andrea L. Crowell; Patricio Riva-Posse; Paul E. Holtzheimer; Steven J. Garlow; Mary E. Kelley; Robert E. Gross; Lydia Denison; Sinead Quinn; Helen S. Mayberg
• Keywords: Treatment-Resistant Depression; Depression; Refractory (planetary science)

Deep brain stimulation of the subcallosal cingulate (SCC DBS) has been studied as a potential treatment for severe and refractory major depressive disorder since 2005. The authors used an open-label, long-term follow-up design to examine participants enrolled in clinical trial SCC DBS treatment-resistant depression.Long-term outcome data were collected 28 patients (20 with seven bipolar II disorder; one patient depression subgroup was later reclassified having disorder) receiving 4-8 years.Response remission rates maintained at ≥50% ≥30%, respectively, through years 2-8 period. Three-quarters all met treatment-response criterion more than half their duration participation study, 21% demonstrating continuous response from first year onward. Of participants, 14 completed ≥8 follow-up, 11 ≥4 years, three dropped out before 8 years. procedure itself generally safe well tolerated, there no side effects acute or chronic stimulation. rate medical surgical complications consistent observed studies other indications. There suicides.In >8 observation, most experienced robust sustained antidepressant DBS.