Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups

• DOI: 10.1176/appi.ajp.2020.19030331
• Publication Date: 2020-06-16T07:01:11Z
• Authors: Premika S.W. Boedhoe; Daan van Rooij; Martine Hoogman; Jos W.R. Twisk; Lianne Schmaal; Yoshinari Abe; Pino Alonso; Stephanie H. Ameis; Anatoly Anikin; Alan Anticevic; Celso Arango; Paul D. Arnold; Philip Asherson; Francesca Assogna; Guillaume Auzias; Tobias Banaschewski; Alexander Baranov; Marcelo C. Batist...; Sarah Baumeister; Ramona Baur-Streubel; Marlene Behrmann; Mark A. Bellgrove; Francesco Benedetti; Jan C. Beucke; Joseph Biederman; Irene Bollettini; Anushree Bose; Janita Bralten; Ivanei E. Bramati; Daniel Brandeis; Silvia Brem; Brian P. Brennan; Geraldo F. Busatto; Sara Calderoni; Anna Calvo; Rosa Calvo; Francisco X. Cast...; Mara Cercignani; Tiffany M. Chaim-...; Kaylita C. Chanti...; Yuqi Cheng; Kang Ik K. Cho; Anastasia Christakou; David Coghill; Annette Conzelmann; Ana I. Cubillo; Anders M. Dale; Sara Dallaspezia; Eileen Daly; Damiaan Denys; Christine Deruelle; Adriana Di Martino; Ilan Dinstein; Alysa E. Doyle; Sarah Durston; Eric A. Earl; Christine Ecker; Stefan Ehrlich; Benjamin A. Ely; Jeffrey N. Epstein; Thomas Ethofer; Damien A. Fair; Andreas J. Fallga...; Stephen V. Faraone; Jennifer Fedor; Xin Feng; Jamie D. Feusner; Jackie Fitzgerald; Kate D. Fitzgerald; Jean-Paul Fouche; Christine M. Freitag; Egill A. Fridgeir...; Thomas Frodl; Matt C. Gabel; Louise Gallagher; Tinatin Gogberash...; Ilaria Gori; Patricia Gruner; Deniz A. Gürsel; Shlomi Haar; Jan Haavik; Geoffrey B. Hall; Neil A. Harrison; Catharina A. Hartman; Dirk J. Heslenfeld; Yoshiyuki Hirano; Pieter J. Hoekstra; Marcelo Q. Hoexter; Sarah Hohmann; Marie F. Høvik; Hao Hu; Chaim Huyser; Neda Jahanshad; Maria Jalbrzikowski; Anthony James; Joost Janssen; Fern Jaspers-Fayer; Terry L. Jernigan; Dmitry Kapilushniy; Bernd Kardatzki; Georgii Karkashadze; Norbert Kathmann; Christian Kaufmann; Clare Kelly; Sabin Khadka; Joseph A. King; Kathrin Koch; Gregor Kohls; Kerstin Konrad; Masaru Kuno; Jonna Kuntsi; Gerd Kvale; Jun Soo Kwon; Luisa Lázaro; Sara Lera-Miguel; Klaus-Peter Lesch; Liesbeth Hoekstra; Yanni Liu; Christine Lochner; Mario R. Louza; Beatriz Luna; Astri J. Lundervold; Charles B. Malpas; Paulo Marques; Rachel Marsh; Ignacio Martínez-...; David Mataix-Cols; Paulo Mattos; Hazel McCarthy; Jane McGrath; Mitul A. Mehta; José M. Menchón; Maarten Mennes; Mauricio Moller M...; Pedro S. Moreira; Astrid Morer; Pedro Morgado; Filippo Muratori; Clodagh M. Murphy; Declan G.M. Murphy; Akiko Nakagawa; Takashi Nakamae; Tomohiro Nakao; Leyla Namazova-Ba...; Janardhanan C. Na...; Rosa Nicolau; Joel T. Nigg; Stephanie E. Novotny; Erika L. Nurmi; Eileen Oberwellan...; Ruth L. O’Gorman ...; Kirsten O’Hearn; Joseph O’Neill; Jaap Oosterlaan; Bob Oranje; Yannis Paloyelis; Mara Parellada; Paul Pauli; Chris Perriello; John Piacentini; Fabrizio Piras; Federica Piras; Kerstin J. Plessen; Olga Puig; J. Antoni Ramos-Q...; Y.C. Janardhan Reddy; Andreas Reif; Liesbeth Reneman; Alessandra Retico; Pedro G.P. Rosa; Katya Rubia; Oana Georgiana Rus; Yuki Sakai; Anouk Schrantee; Lena Schwarz; Lizanne J.S. Schw...; Jochen Seitz; Philip Shaw; Devon Shook; Tim J. Silk; H. Blair Simpson; Norbert Skokauskas; Juan Carlos Soliv...; Anastasia Solovieva; Noam Soreni; Carles Soriano-Mas; Gianfranco Spalletta; Emily R. Stern; Michael C. Stevens; S. Evelyn Stewart; Gustavo Sudre; Philip R. Szeszko; Leanne Tamm; Margot J. Taylor; David F. Tolin; Michela Tosetti; Fernanda Tovar-Moll; Aki Tsuchiyagaito; Theo G.M. van Erp; Guido A. van Wingen; Alasdair Vance; Ganesan Venkatasu...; Oscar Vilarroya; Yolanda Vives-Gil...; Georg G. von Polier; Susanne Walitza; Gregory L. Wallace; Zhen Wang; Thomas Wolfers; Yuliya N. Yoncheva; Je-Yeon Yun; Marcus V. Zanetti; Fengfeng Zhou; Georg C. Ziegler; Kathrin C. Zierhut; Marcel P. Zwiers; ; ; ; Paul M. Thompson; Dan J. Stein; Jan Buitelaar; Barbara Franke; Odile A. van den ...
• Keywords: Male; Research Report; Obsessive-Compulsive Disorder/diagnosis; Obsessive-Compulsive Disorder; Attention Deficit Hyperactivity Disorder; Systems Analysis; Autism Spectrum Disorder; Autism; [SDV]Life Sciences [q-bio]; Biological Psychology; 150; Clinical sciences; Medical and Health Sciences; Clinical and health psychology; 0302 clinical medicine; 130 000 Cognitive Neurology & Memory; Attention Deficit Disorder with Hyperactivity/diagnosis; Psychology; 2.1 Biological and endogenous factors; Neuroimaging/methods; Child; Pediatric; Psychiatry; Cerebrum/diagnostic imaging; Psychopathology; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; ABNORMALITIES; ENIGMA; /dk/atira/pure/subjectarea/asjc/2700/2738; Organ Size; Psychiatry - Radboud University Medical Center; Mental Illness; 3. Good health; [SDV] Life Sciences [q-bio]; Mental Health; Neurological; Biomedical Imaging; Mental health; Female; MRI; Adult; CORTEX; Adolescent; DEFICIT HYPERACTIVITY DISORDER; Intellectual and Developmental Disabilities (IDD); 1.1 Normal biological development and functioning; Human Development; 610; Neuroimaging; 03 medical and health sciences; FIELD-STRENGTH; name=Psychiatry and Mental health; Clinical Research; 616; Behavioral and Social Science; MEGA-ANALYSIS; ENIGMA ASD working group; Humans; Attention Deficit Hyperactivity Disorder; Autism Spectrum Disorder; ENIGMA; Obsessive-Compulsive Disorder; Structural MRI; Adolescent; Adult; Child; Female; Human Development; Humans; Male; Neuroimaging; Organ Size; Psychopathology; Research Report; Systems Analysis; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Cerebrum; Obsessive-Compulsive Disorder; Cognitive Neuroscience - Radboud University Medical Center; Cerebrum; Autism Spectrum Disorder/diagnosis; Biomedical and Clinical Sciences; Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience; AUTISM SPECTRUM DISORDER; Psychology and Cognitive Sciences; Neurosciences; OBSESSIVE-COMPULSIVE DISORDER; Attention Deficit Hyperactivity Disorder (ADHD); ENIGMA OCD working group; Brain Disorders; ENIGMA ADHD working group; Structural MRI; VOXEL; Attention Deficit Disorder with Hyperactivity; Human Genetics - Radboud University Medical Center; Human Development/physiology

Attention deficit hyperactivity disorder (ADHD), autism spectrum (ASD), and obsessive-compulsive (OCD) are common neurodevelopmental disorders that frequently co-occur. The authors sought to directly compare these using structural brain imaging data from ENIGMA consortium data.