Psychiatric Manifestations as Primary Symptom of Neurosyphilis Among HIV-Negative Patients

• DOI: 10.1176/appi.neuropsych.13030064
• Publication Date: 2014-04-15T13:31:11Z
• Authors: Li-Rong Lin; Hui-Lin Zhang; Song-Jie Huang; Yan-Li Zeng; Ya Xi; Xiao-Jing Guo; Gui-Li Liu; Man-Li Tong; Wei-Hong Zheng; Li-Li Liu; Tian-Ci Yang
• Keywords: Neurosyphilis

This study characterizes psychiatric manifestations as a primary symptom of neurosyphilis (NS). Fifty-two the 169 NS patients presented with manifestations, many had characteristics more than one syndrome, including cognitive impairment, personality disorders, delirium, hostility, dysarthria, confusion, disruption their sleep-wake cycle, fecal and urinary incontinence, dysphoria, paranoia, hallucinations, expansive mood, mania. positive sera RPR T. pallidum particle agglutination (TPPA), 75% CSF RPR, 96.2% TPPA, 44.2% pleocytosis elevated proteins, 70.0% nonspecific, abnormal brain MRIs. These results indicate that mimics almost all disorders.