Robust Circadian Rhythmicity of Per1 and Per2 Mutant Mice in Constant Light, and Dynamics of Per1 and Per2 Gene Expression under Long and Short Photoperiods

• DOI: 10.1177/074873040201700303
• Publication Date: 2009-04-17T22:54:26Z
• Authors: Stephan Steinlechner; Birgit Jacobmeier; Frank Scherbarth; Haiko Dernbach; Friederike Kruse; Urs Albrecht
• Keywords: PER1; PER2

The Per1 and Per2 genes are components of the mammalian circadian clock. Mutations in these alter phase resetting response to a nocturnal light pulse, mutant mice known become arrhythmic constant darkness. We show that under conditions, exhibit robust activity rhythms as well body temperature with period length is less than 24 h. In mutants, both longer h light. mutants prolong their (tao) when illuminance increased, whereas shorten endogenous period. Additionally, authors pattern gene expression modified different photoperiods there mutual influence on timing expression. propose that, mice, relationship between might be critical for transducing day information organism. could part morning oscillator tracking dawn, an evening dusk.